Since I am using dasBlog as my blogging system it has been difficult to get access to popular blogging layouts a la Word Press. dasBlog has actually been around for so long that most of the existing templates have heavy doses of tables to support the layout, and for most web designers that is a real problem.
I have slowly been converting the blog to a more div oriented layout, however, in order to support a greater diversity of devices and layouts I am considering a move to a CSS responsive grid system. CSS grid systems promote beautiful and responsive site layouts. You can certainly create your own (and I intend to do so) but there are a few open source options out there, and here are some of my favorite:
Profound Grid - A responsive grid system for fixed and fluid layouts. Built in SCSS, it gives you flexibility and full control.
Responsive Grid System – This isn't a framework. It's not a boilerplate either. It's a quick, easy & flexible way to create a responsive web site
rwdgrid - Just another Grid system based on popular 960grid , which is responsive and ranges from mobile, tablet, laptops and wide screen displays
csswizardry-grids - A fully responsive, mobile-first, infinitely nestable, reversible, reorderable, simple to understand, human-friendly, robust grid system.
Skeleton - A small collection of CSS files that can help you rapidly develop sites that look beautiful at any size, be it a 17" laptop screen or an iPhone. Skeleton is built on three core principles.